ILOs:

• State that in the diagnosis and management of liver disease, it is important to distinguish between space occupying lesions or masses, and diffuse liver disease
• List these common histological patterns of diffuse liver disease: acute hepatitis, acute cholestasis/ cholestatic hepatitis, fatty liver disease, chronic hepatitis, chronic biliary disease and hepatic vascular disease. For each, briefly describe their clinical and/or histological appearances, and their most common causes and/or underlying disease processes
• Explain, with examples, that drug-induced liver disease is common and may present as almost any pattern of liver disease
• For space occupying (mass) lesions, explain that the main differential diagnosis is between inflammatory lesions e.g. abscesses, and neoplasms
• List and describe commonly encountered hepatic neoplasms including primary liver tumours and metastases
• Describe the common clinical manifestation of liver disease and understand the mechanisms by which liver disease leads to these
• Discuss how to investigate a patient with liver disease
• Describe the common management strategies for patients with liver disease

• Relevant teaching to revisit after this lecture
• Describe the normal liver macro and microstructure
• Define “acute”, “chronic” and “acute-on-chronic” with regards to inflammation and liver injury
• What is cirrhosis?
• Graph showing the increasing prevalence of liver disease…
• What are the key features of the clinical history of liver disease?
• Outline the LFTs and what may be occurring when they are deranged
• Which tests are most important to look at the function of the liver

Diffuse Liver Disease - Acute Patterns

• What are the different patterns of diffuse liver disease