ILOs

• Understand the clinical need for, and potential benefits of, targeted cancer therapies.
• Understand the difference between predictive and prognostic markers.
• Discuss examples of one or more targeted therapies that is in routine use to treat cancer patients.
• Understand some of the challenges in developing new targeted cancer therapies.

• Example patient case study
• How does PD-1/PDL-1 work?
• A metaphase spread from a patient with CML
• What is CML?
• Explain the pathophysiology of CML
• Let’s remember how tyrosine kinases work...
• Wow, throwback to the RAS pathway.
• What is Abl?
• But what happens in CML?
• What’s imatinib?
• Are all targets in the cancer cell itself?
• Examples of different tyrosine kinase inhibitors in practice
• Hormone treatment for prostate cancer
• The question is... aren’t all drugs targeted?