ILOs

• Revise the structure of proteins
• Describe the processes of protein folding
• Explain how misfolded proteins are detected and removed
• Describe the consequences of protein misfolding in neurodegenerative diseases

• What are proteins?
• Diagram showing the different modifications that proteins can undergo
• Diagram outlining different classes of proteins
• What factor determines the function of a protein, and what does this depend on?
• What is the difference between different amino acids?
• What might the consequences of a mutation be?
• A reminder of protein structure
• How does the secondary structure arise?
• What is the tertiary structure?
• Explain what proteostasis is
• Outline the different protein degradation pathways
• Have a look at the fate of a newly synthesised protein, bro
• Facts we just need to understand when thinking about protein folding
• It’s never that simple though! Remember this stuff...