ILOs

• To describe how key pharmacokinetic variables are altered in renal disease
• To describe how key pharmacokinetic variables are altered in hepatic disease
• To describe areas where care is needed in the elderly due to PK / PD changes

PK/PD Revision…

• Let’s remind ourselves of the definition of pharmacokinetics…
• Let’s now remind ourselves of the definition of pharmacodynamics…
• So, what is bioavailability?
• Now, what is apparent volume of distribution?
• What is clearance?
• Explain what half-life is for a drug…
• Look at the equation for half-life…
• A graph showing us half-life…
• Here are some principles of linear pharmacokinetics…
• In linear pharmacokinetics, how is the rate of elimination, concentration and dose linked?
• What about in non-linear pharmacokinetics?
• Look at how concentration is linked to dose in non-linear pharmacokinetics…

Special Circumstances - Age

• What happens to our pharmacokinetics with age?