ILOs

• Understand the range of reasons as to why someone who is a heavy drinker might be suffering from cognitive impairment.
• Describe how alcohol itself has been discovered to be neurotoxic alongside the neurotoxicity which results from malnutrition, particularly Vitamin B1 deficiency and in some cases also from liver disease.
• Give an overview of the types of neuropsychological deficits which result and the correlations of these deficits with structural and functional brain changes as evidenced both in life and at post mortem.

• What are some psychological harms relating to regular heavy drinking?
• Outline the numbers of patients with alcohol-related brain damage around Glasgow
• The majority of patients seen with ARBD have Korsakoff Syndrome/Alcohol Amnestic Disorder
• What are the cognitive functions that are often impaired in alcoholism
• Outline some common alcohol related brain damage syndromes
• What factors predispose patients to alcohol related brain damage
• What is the Wernicke-Korsakov Syndrome? (Alcohol amnestic syndrome)
• What is thiamine and its stores in the body?
• What are the 3 cardinal symptoms of Wernicke-Korsakov syndrome and what are the neurological lesions that contribute to it?
• Thiamine deficiency syndromes can be seen in many different species
• What are the common mental and behavioural abnormalities in patients presenting with WKS?
• What is the definition of amnestic syndrome?
• What is alcohol dementia?
• What are the cardinal syndromes for alcohol dementia?
• What are some bedside mental status tests?