ILOs

• outline the pathogenesis of axonal and demyelinating processes in peripheral neuropathy;
• describe common clinical patterns of neuropathy (including distal symmetrical length- dependent polyneuropathy);
• Describe clinical features of muscle disease;
• use Myasthenia Gravis as an example of disorder of neuromuscular junction
• Recognise the clinical presentations of radial, ulnar, median, common peroneal and femoral neuropathies.

Pre-Lecture Cases

• Here’s the case of a 45 year old male…
• Now, a 71 year old gentleman…
• Over to this 69 year old female, with her case!

Lecture

• What is the peripheral nervous system, and what are its functions?
• Where does information enter the peripheral nervous system, and exit?
• How are peripheral nerve fibres organised?
• Here’s a diagram showing us the anatomy of the PNS…
• Look at the diagram of the neuromuscular junction…
• What does the clinical presentation of neuropathy depend on?
• Outline what length-dependent axonal neuropathy is…
• Describe the causes of length-dependent axonal neuropathy…