ILOs:

• Revise how cells proliferate (i.e. their passage through the Cell Cycle)
• Discuss the ways in which signalling molecules can lead to changes in cell behaviour (e.g. proliferation) (i.e. signal transduction)
• Describe the role of chondrocytes and their precursors in endochondral bone growth
• Outline the characteristic features of achondroplasia and the molecular defect responsible for the condition
• Discuss how mutation of molecules in signal transduction pathways could lead to aberrant signalling

• Revise how cells proliferate (i.e. their passage through the Cell Cycle)
• Discuss the ways in which signalling molecules can lead to changes in cell behaviour (e.g. proliferation) (i.e. signal transduction)
• Describe the role of chondrocytes and their precursors in endochondral bone growth
• Outline the characteristic features of achondroplasia and the molecular defect responsible for the condition
• Discuss how mutation of molecules in signal transduction pathways could lead to aberrant signalling.

PBL 5 - Achondroplasia.pdf