ILOs

• Describe the epidemiology, clinical features, diagnosis and histopathological features of the four main neurodegenerative forms of dementia (Alzheimer’s Disease, Dementia with Lewy Bodies, Vascular Dementia and Frontotemporal Dementia).

• What is dementia?
• Outline the clinical features of dementia
• How do we diagnose dementia types?

Alzheimer’s Disease - Pathology

• Outline the main macroscopic pathological findings in Alzheimer’s
• Outline the main microscopic pathological findings in Alzheimer’s
• Describe the process of the deposition of tau in Alzheimer’s onset
• Describe the process of the deposition of beta-amyloid plaques in Alzheimer’s onset
• Summary of the pathology of Alzheimer’s

Alzheimer’s Disease - Epidemiology

• Outline the epidemiology of Alzheimer’s disease
• Describe the risk factors and protective factors for dementia generally
• Outline the key gene mutation predisposing for Alzheimer’s
• Outline some sporadic vs genetic dementias

Dementia with Lewy Bodies - Pathology

• Outline the main macroscopic pathological findings in DwLB
• Outline the main microscopic pathological findings in DwLB