Megaloblastic Anaemia and Haemoglobinopathies | Notion

ILOs

To describe the requirements for normal red cell production
To explain the pathophysiology of anaemia
To be able to provide examples of diseases causing anaemia
To develop a logical approach to the investigation of a patient with anaemia

What are the factors that normal red cell production is dependent on?
What is the imbalance that leads to anaemia?
What is the imbalance that leads to polycythemia?

Megaloblastic Anaemia

What is the primary cause of megaloblastic anaemia?
Why is B12/Folate important in erythropoeisis?
What’s the difference between megaloblastic and macrocytic anaemia?
What processes is B12 necessary for?
What are the sources of B12?
What is the dietary requirement of B12 per day?
How is B12 absorbed from the intestine?
How much B12 is lost per day?
How long is B12 stored for?
What are the dietary sources of folate?