Malignant Conditions of the Breast

Factors modifying breast cancer risk in individuals and populations, including genetic influences, age, and childbearing.
Relationships between breast cancer and likely precursor lesions including so-called ‘ductal’ and ‘lobular’ epithelial hyperplasia (± atypia), and carcinoma in situ; Invasive breast cancer, and its morphological and molecular classification.
How it is diagnosed (physical signs, imaging, cytology, biopsy) and the importance of grading, steroid hormone receptor expression and Her2 status.
The Nottingham prognostic index.
Non-carcinoma breast malignancies (lymphomas, sarcomas, malignant phyllodes tumours).

Which cancer kills the most women in the UK?
What is the incidence with age for breast cancer, and what is the median age of diagnosis?
What is the male to female ratio for breast cancer?
List the risk factors for breast cancer…
Outline some of the genetic breast cancer syndromes…
What is thought to be protective against breast cancer?
What are the symptoms we need to remember with possible breast cancer?
How do we investigate breast abnormalities?
Here’s a normal mammogram, versus a mammogram showing us a lesion…
Now, here’s a histology slide showing us microcalcification…
How do we treat breast cancer?
Image showing us a wide local excision of a 15mm carcinoma…
A histology slide showing us the histology of invasive carcinoma in wide local excision…