ILOs

• understand the pathophysiology, investigations and treatment of
  • Kallmann’s syndrome
  • Primary Gonadal Disease
  • Kleinfelters
  • Hypogonadotrophic hypogonadism
• understand the rationale and potential advantages and disadvantages of testosterone replacement.

• Let’s remind ourselves of the anatomy of the male gonads…
• Let’s talk about how testosterone is produced….
• How is gonadal function controlled?
• What are the biological effects of testosterone?
• Outline the functions of the testes…
• So, what are the clinical features of hypogonadism?
• What things come under our clinical assessment of hypogonadism?
• So, how do we test for suspected hypogonadism?
• Look how we categorise hypogonadism based upon where the problem is…
• Outline the causes of hypogonadotrophic hypogonadism…
• Explain what Kallmann’s Syndrome is…
• What is the epidemiology and genetic cause of Kallmann’s Syndrome?
• Outline the causes of primary gonadal disease…
• What is Klinefelter’s Syndrome?
• Outline the variation in phenotype of Klinefelter’s Syndrome, and management…
• So, can testosterone be replaced?