ILOs

• Describe risk factors for the occurrence of thrombi in commonly affected locations; the role of endothelial dysfunction, altered blood flow and hypercoagulability in thrombosis; and how thrombi form and may be resolved by intrinsic means.
• Discuss the consequences, including ischaemia and infarction, of venous, arterial, and intracardiac thrombosis and embolism in typically affected locations and tissues, and the consequences for patients; and provide examples of these including pulmonary embolism and heart disease
• Indicate when thrombosis prophylaxis is appropriate and how it may be achieved; discuss common presentations of thrombosis or thromboembolism; and say how these scenarios would typically be investigated and treated.

• What’s the link between thrombosis and haemostasis?
• A diagram showing us normal haemostasis…
• Outline the role of von Willebrand factor in primary haemostasis…
• Here’s a diagram of the coagulation pathways, showing the intrinsic and extrinsic activation
• Outline the different risk factors that may cause thrombosis and how we categorise them…
• Compare and contrast the two different types of thrombi we find in our circulatory system…

Case 1

• Here’s the history of our patient…
• Let’s take a look at how things developed from there though…
• What are the differentials to consider with a sore leg?
• Based on the history and differentials… what is the most likely diagnosis?
• What is a DVT and where is it commonly found?
• A graph showing us how the incidence of VTE increases with age…
• What are the risk factors for DVT?
• Let’s think about this patient’s specific risk factors…