ILOs
- Identifying the patient who requires medication adjustment because of liver dysfunction
- Understanding the pharmacokinetics and pharmacodynamics in patients with chronic liver disease and how this affects prescribing of medications
- Initiating symptom management in patients with advanced liver disease
- Let’s outline the case of our gentleman…
- Here’s how he presents to IAU…
- Here’s how our patient is managed…
- But then, look what happens 2 days later…
Clinical Pharmacology
- Let’s remind ourselves of basic pharmacokinetics…
- How does liver disease affect absorption of drugs?
- How does liver disease affect the distribution of drugs?
- Explain how liver disease affects the metabolism of drugs…
- How does liver disease affect drug excretion?
- What else should we consider with liver disease?
- What should we be mindful of with paracetamol prescribing in liver disease?
- Here’s how we use opioid analgesics in liver disease…
- A summary of principles when prescribing in liver disease…
Symptom Management in Advanced Liver Disease