ILOs:

• Explain how compatibility between donor organs and recipients is determined
• Understand how major histocompatibility complex matching is critical in transplantation
• Understand the factors contributing to and the various types of transplant rejection
• Understand how donor organs are allocated to recipients in the UK

Part 1: Histocompatibility

• Defining the following terms...
• What types of allogeneic donors do we have?
• A table showing the survival rates for certain transplants
• A graph showing people awaiting a solid organ transplant in the UK
• The big dilemma that medical professionals face with this thing...
• What is the UK organ allocation system?
• How is compatibility between organ donors and recipients determined?
• What is the major histocompatibility complex?
• A cartoon diagram of a HLA class I molecule
• An explanation of CD8 T cell and HLA class I interaction
• A cartoon diagram of a HLA class II molecule
• An explanation of how HLA class II molecules bind peptides
• Let's consider an APC with HLA class I and class II molecules