ILOs:

• Explain why cell signalling is important in medicine
• Demonstrate understanding of basic principles of cell signalling
• Define basic signalling-related terminology
• Classify signalling molecules according to their chemical nature, their range of action and/or their mechanism of action
• Outline the general mechanism of signal transduction for hydrophobic signals; and explain how lipophilic steroid hormones elicit their effects
• Explain the general mechanisms for signal transduction via three key cell surface receptor types: the receptor tyrosine kinase (RTK) class of enzyme-coupled receptors, ion-channel-linked receptors, and G-protein-coupled receptors (GPCRs); and give physiological examples of each
• Give examples whereby pharmacology exploits our understanding of signal transduction

• What is cell signalling?
• Integration of multiple signals
• Signalling in medicine
• Types of signals
• Stages of signalling
• Multiple signalling pathways
• Cancer