ILOs:

• Describe the role of the liver in carbohydrate, fat and protein metabolism
• Relate signs and symptoms of liver failure to biochemical abnormalities
• Describe the role of liver in providing endogenous supply of glucose
• Describe the role of liver in the metabolism and distribution of fats
• Describe the lipoprotein-based fat and cholesterol transport system and its role in energy metabolism
• Describe the role of liver in protein metabolism and elimination of nitrogen
• Discuss wide ranging pattern of protein synthesis, and changes of such pattern in disease

Part 1: Metabolic functions of the liver

• Review: Describe the gross anatomy of the liver
• Review: Describe the histology of the liver
• What is the Metabolic zonation in the liver?
• How are carbohydrates metabolised?
• What happens during glycolysis?
• How are lipids metabolised?
• What happens to cholesterol in the body?
• How are proteins metabolised?
• What happens to AA?
• What is the urea cycle and what is its purpose?