ILOs

• Apply the knowledge of bone metabolism to describe the pathogenesis of metabolic bone disorders
• Formulate a plan for investigation and diagnosis of common metabolic bone disorders
• Develop an understanding for the basis of treatment

• Cells in bone
• What is bone remodelling?
• Concept of Bone metabolic unit (BMU)
• Bone growth/remodelling
• RANKL/RANK/OPG pathway
• Role of OPG in regulation of BMD
• Composition of bone
• Age related changes in bone mass
• Determinants of peak bone mass
• What are metabolic bone disorders?
• Osteoporosis
• Normal physiology of PTH/Ca
• Primary hyperparathyroidism
• Paget's disease
• Osteopetrosis