ILOs
- To define what is meant by a neurodegenerative disorder
- To outline the role of abnormal protein deposition in the pathogenesis of neurodegenerative disorders
- To recognise the role of beta amyloid plaque formation and tau deposition in the pathogenesis of Alzheimer’s disease
- To recognise Parkinson’s disease (PD), Dementia with Lewy Bodies (DLB) and Multiple Systems Atrophy (MSA) as examples of alpha-synucleinopathies
- To recognise Creutzfeldt Jakob Disease (CJD) as an example of a prion disorder
- To recognise Huntington’s Disease as an example of a trinucleotide repeat disorder
- What is meant by the term neurodegenerative disease?
- Outline a few generalisations about NDDs
- What does the clinical spectrum of NDD include?
Alzhiemer’s disease and other tauopathies
- What do we mean when we refer to tau?
- What is the role of MAPT?
- What can hyperphosphorylation of tau lead to?
Alzhiemer’s
- What is Alzheimer’s?
- How does Alzheimer’s present clinically?
- What is the pathology of Alzheimer’s?
- What does Alzheimer’s result in?