ILOs:

• Discuss the concept of autoimmunity and how the immune system in this context differs from a healthy immune system
• Give an account of the mechanisms underlying autoimmune disease
• Explain how the immune system can attack self and cause injury
• Explain how therapeutics can be used to target pathways in disease pathogenesis

Part 1 - Causes

• What is autoimmunity?
• What are the causes of autoimmune diseases?
• List general features of autoimmune diseases
• What are the general causes of autoimmune disease?
• Regulation - 'default' in the immune system?
• List common environmental challenges to the immune system
• What role do infections have in autoimmune diseases?

Part 2 - Mechanisms

• What is the general pathogenesis of autoimmune diseases?
• Immune-mediated inflammatory diseases
• Autoantibodies
• List common cellular mechanisms in autoimmunity