ILOs:

• Describe the regulation of gastric secretions
• Discuss the pathophysiology of peptic ulcer disease and the role of H. Pylori
• Discuss the pharmacological basis of the treatment of peptic ulcer and H. Pylori
• Discuss the epidemiology of peptic ulcer disease

https://www.youtube.com/watch?v=Rcb6I7gsl-Y

Part 1 - H. pylori transforming our understanding of UGI disease

• When was H. pylori discovered and by whom?
• What does a duodenal ulcer look like?
• Describe key epidemiology of duodenal ulcers?
• Describe key aetiology of duodenal ulcers
• Briefly describe the regulation of acid secretion (including what occurs in different phases).
• What were the historic treatments of DU disease?
• What mechanism allows H. pylori to survive in the acidic gastric environment?
• What are the differences in H. pylori infection prevalence in the developed vs developing world?
• What was the first evidence that linked H. pylori infection to DU disease?

Part 2 - DU disease pathophysiology

• How does H. pylori infection result in increased gastrin release?
• Outline the pathophysiology of DU disease due to H. pylori infection