Part 1 - The Neural Tube

ILOs

• Describe neural tube development and explain the role of induction in this process
• Describe neural tube defects
• Understand the role of induction in development
• Understand the role of Sonic Hedgehog in controlling bending and patterning of the neural plate
• Understand how increased Sonic Hedgehog signalling is involved in neural tube defects

Development of the Neural Tube

• What happens in gastrulation?
• What are the germ layer derivatives?
• What are the beginnings of the neural tube?
• An example of induction in development
• How does the notochord and mesoderm cause development of the neural plate?
• Give an overview of neural tube formation
• Diagram showing neural tube formation
• Explain the mechanisms controlling bending of the neural plate
• Diagram of neurulation
• Explain how the neural tube closes

Neural Tube Defects