ILOs:
- Understand the mechanisms involved in renal excretion of drugs
- Describe how impaired kidney function has an effect on drug metabolism and clearance
- Explain the dose adjustment options necessary in patients with compromised kidneys
- Understand the mechanisms and clinical presentation of nephrotoxicity
- Understand the use and misuse of diuretics
- Outline the drug journey through the nephron and the potential areas of action
- What are the mechanisms of renal handling of drug excretion?
- Outline some drug families that are excreted unchanged by the kidneys
- What is the general pattern of drug plasma concentration in relation to the kidneys?
- Outline some drug compositions and how they affect renal excretion
- What is the effect of impaired renal function on drug therapy?
- Outline the example of gentamycin (and general) prescribing on impaired renal function
- What is the effect on drugs with altered structure of albumin?
- Why do we get altered pharmacokinetics in impaired kidney function?
- What is the effect of altered drugs through kidney disease in the body?
- What can reduced excretion cause and what are some drugs that are most affected?
- What factors should we consider when adjusting dosage in renal impairment?
- When should we adjust drug dosage regimens in the presence of renal failure? Give examples.