Lecture: Drug Treatment of Angina

Understand the origins of stable, unstable and variant angina
Explain why lowering myocardial O2 demand is the major therapeutic strategy in drug treatment of all forms of angina
Explain why reducing preload with venous dilators or afterload with arterial dilators brings benefit in all forms of angina
Describe the major classes of drugs used to treat angina, including their actions, mechanisms and sites of action, clinical effectiveness, side effects and limitations
Make use of the NICE algorithm for treating angina

What is Angina?
How does ischaemia develop
What are the 3 types of angina and their features?
What is the epidemiology of angina? Differences in men and women?
Histological slide of an atherosclerotic artery
Atherosclerotic artery in angiogram
What is the effect of dilation of coronary arteries in treating angina? What are the benefits and negatives?
What drugs do we have to reduce myocardial oxygen demand?
What are the unmet needs of current therapy for angina?
NICE treatment protocol for stable angina