ILOs:

• Describe in detail the biochemistry of bile pigments, especially Bilirubin, and explain how it is transformed from a hydrophobic "un-conjugated" form to a hydrophilic "conjugated" form by the liver
• Explain how the distinct chemical properties of bile salts are important for their function in lipid digestion
• Describe the mechanisms by which bile secretion from the gall bladder is controlled
• Describe the basis for the classification of jaundice into three groups (pre-hepatic, hepatic and post-hepatic) and uses of the distinct effects on Bilirubin metabolism

Part 1 - Normal Bilirubin Metabolism

• Where is bile generated and stored?
• What are the general components of bile? (5)
• What is the principle bile pigment?
• How is bilirubin generated?
• Outline the process of haem group breakdown to formation of bilirubin
• What colour is bilirubin? Is it hydrophobic or hydrophilic?
• What is the process of bilirubin conjugation in the liver?
• What is the process of bilirubin metabolism from the RE system to the bile duct?
• What is the process of enteric bilirubin metabolism?
• What are the main bile salts?
• How does the chemical structure of bile salts contribute to function?
• How do bile salts promote emulsification?
• How do bile salts promote micelle formation?