Lecture: Anticoagulants, Antithrombotics and Thrombolytics

Describe the actions and mechanisms of action of anticoagulant agents used to prevent venous thrombosis or to permit storage of blood outside the body for analysis or transfusion
Describe the actions and mechanisms of action of antiplatelet drugs used to treat arterial thrombosis
Describe the actions and mechanisms of action of fibrinolytic agents used to dissolve blood clots in medical emergencies such as myocardial infarction and thrombotic stroke
Understand the clinical utility and side effect profile of anticoagulants, antithrombotics and thrombolytics

Give examples of in vitro anticoagulants?
Give examples of in vivo anticoagulants?
Describe the mechanism of action for Heparin
In contrast, what does LMWH targe/inhibit?
What is the difference between Heparin and LMWH?
Descibe the advantages and disadvantages of LMWH - which to use?
What is the process of administration of Heparin & LMWH?
What can Heparin and LMWH be used for?
What are the side of Heparin?
How would you reverse these side effects?
As Heparin is administered through injections, what is an exmaple of an Oral Anticoagulant?
The discovery and exploitation of the actions of Warfarin
Describe the mechanism of action of Warfarin?
Describe the uses of warfarin