ILOs:

• Understand the important physiological processes underlying drug metabolism and excretion
• Describe the important of half life and steady state concentration in the prescribing of drugs
• Recognise the potential for drug-drug interactions and the important mechanisms by which these can occur
• Be aware of the added complications involved in using drugs which involve non-linear kinetics.

• Clearance and half life
• What is clearance?
• What is the relationship between volume of distribution and mass of drug cleared?
• What is half life? What is the equation used to calculate it?
• What is the relationship between clearance, volume of distribution and half life?
• How does gentamycin go against this?
• What are the routes of clearance?
• How to estimate renal clearance?
• What is the implication on elimination with an exponential decay of clearance?
• Summary of clearance and half life
• Mechanisms of drug clearance
• Why do we need drug metabolism?
• What are the phases of drug metabolism?
• Phase 1 and 2 metabolism in aspirin