ILOs:

• Describe the general principles of pharmacokinetics using the ADME mnemonic.
• Focusing on the common routes of drug administration, outline the reasons why a drug route may be selected
• Explain the relationship between drug dose and serum concentration with reference to the volume of distribution and how this is used to derive loading and top up doses
• Understand the role of drug absorption and first pass metabolism in contributing to bioavailability

Part 1 - The relevant pharmacodynamics

• What factors govern drug regimens?
• What is the main goal of pharmacokinetics?
• What is the ADME acronym in pharmacokinetics?

Part 2 - Absorption

• How are drugs delivered (local vs systemic)?
• Give examples of common drug delivery routes for local, enteral and parenteral action
• What are the principles of selecting an appropriate route for drug delivery?
• Outline the principles of IV drug administration
• Outline the principles of IM drug administration
• Outline the principles of oral drug administration
• Outline the principles of inhalation as a route for drug administration

Part 3 - Distribution

• What is the 2 compartment model of drug distribution?