Inherited Predisposition to Cancer

understand the importance of genes in cancer and to know about somatic and inherited mutations
recognise the differences between tumour suppressor genes, proto-oncogenes and oncogenes
understand the two-hit hypothesis
know the molecular basis of the contribution to cancer of several important cancer genes, including their role in pathways such as DNA repair
know which features in a personal and family history can suggest a significant cancer predisposition syndrome
be aware of relevant and up-to-date online information sources

What capabilities must be acquired for a cell to develop into cancer?
How is the cell cycle controlled?
What are DNA repair genes?
How can we divide the types of cancer up?
How are the more common cancer predisposition syndromes generally inherited, and what causes it?
What is the lifetime risk for cancer?
What do we look for when looking for a significant cancer predisposition syndrome?
What services can be offered in a cancer family history clinic?
What percentage of breast cancer is familial, and what causes it?
If BRCA1 is mutated, what is your risk of breast cancer?
If BRCA2 is mutated, then what is your risk of breast cancer?
How many low-penetrance loci are there for breast cancer?