ILOs

• Introduction to haemopoietic stem cell disorders
• Importance of bone marrow microenvironment
• Develop basic understanding of clonal disorders of haemopoietic stem cells
  • over-production: myeloproliferative disorder
    • example: Jak2 positive ET
  • under-production: aplastic anaemia
    • example: Fanconi’s anaemia
  • abnormal cells produced: myelodysplasia, leukaemia
    • example: refractory anaemia with excess blasts and monosomy 7
• Understand basic concepts of stem cell mobilisation and stem cell transplant

• What is haemopoiesis?

• How do the sites of haemopoiesis change during stages of life?

• Outline the hierarchy of normal haemopoiesis

• List the characteristics of haemopoietic stem cells…

• Pictures showing examples where haemopoietic stem cells are found

• What are the different fates of haemopoietic stem cells?

• What types of division can stem cells undergo, and which factors control stem cell fate?

• What is the bone marrow microenvironment?

• A diagram showing bone marrow architecture

• Pictures showing us different appearances of bone marrow

• Scanning electron microscope image of bone marrow

• How do we categorise the conditions impairing bone marrow function? List them.

• Explain the principles of leukaemogenesis