ILOs
- To describe the requirements for normal red cell production
- To explain the pathophysiology of anaemia
- To be able to provide examples of diseases causing anaemia
- To develop a logical approach to the investigation of a patient with anaemia
- What is haemolytic anaemia?
- What is the red cell lifespan and what are the effects of reduction of this?
- How do we classify the haemolytic anaemias?
- Outline the common congenital haemolytic anaemias (and explain HS)
- Describe and explain the common RBC enzyme-related haemolytic anaemias
- Outline the common acquired haemolytic anaemias
- What are the features seen on blood film of a patient with fragmentation haemolysis?
- What are the causes of red cell fragmentation?
- Outline cold autoimmune haemolytic anaemia and its causes
- What are the features seen on blood film of those with cold autoimmune haemolytic anaemia?
- Outline warm autoimmune haemolytic anaemia and its causes
- What are the features seen on blood film of those with warm autoimmune haemolytic anaemia?
- How does drug-induced haemolysis take place?
- How do we detect autoimmune haemolytic anaemia and antibodies on RBC surface? (Coombs Test)