ILOs

• appreciate dysfunction of the immune system has clinical implications
• know basics about the presentation, diagnosis, investigation and management of the more common connective tissue diseases (SLE, Sjogren’s, systemic sclerosis and myositis)
• understand that multisystem disease can be a feature of rheumatic diseases

Systemic Lupus Erythematosus

• Outline the prevalance of SLE, which populations it is more common in, when the symptoms onset and the rough age of diagnosis…
• Are there racial differences with suffering from SLE? Why is SLE important, and how does it affect the time of your death? What’s the survival rate?
• Here’s a table showing us the classification criteria of SLE from the European and American Rheumatology societies…
• How does the clinical presentation of SLE vary?
• Do cutaneous manifestations always mean you have SLE?
• What are the musculoskeletal manifestations of SLE?
• Outline some other musculoskeletal manifestations of SLE…
• How many patients will have renal involvement in SLE? What can we use renal biopsy for in SLE?
• What pulmonary manifestations can we get with SLE?
• And, what about the cardiovascular manifestations of SLE?
• How does SLE manifest with neuropsychiatric symptoms?
• Let’s talk about the gastrointestinal manifestations of SLE…
• What sort of haematological manifestations can we get with SLE?
• What is the first line investigation for SLE?