Cell Injury, Degeneration and Death

Discuss the broad causes and mechanisms of cell injury, and provide examples.
Describe the responses of cells to injury, including reversible and non-reversible.
Give clear definitions of necrosis (including types) and apoptosis and describe the circumstances in which they arise, and provide examples.
Outline the nature, causes and effects of amyloid, pathological pigmentation and calcification, and provide examples.

Part 1: Theory

Outline the different causes of cell injury…
How does the severity of a cell injury determine the outcome, and what are the two ways in which severe injury can result in cell death?
Outline the different parts of a cell that can be injured, and the consequences…
Explain what oxidative stress is…
What does reversible cell injury look like?
A pictogram of normal cells, reversible cell injury, and irreversible cell injury
Compare and contrast cell death by necrosis and apoptosis
Explain the histological changes in cell necrosis
A diagram showing us the nuclear changes in necrosis
Slides showing us necrosis in myocardium
And then… as the necrosis develops…
Outline the morphological subtypes of necrosis…
Outline the effects of necrosis…