Antibiotics and Resistance

demonstrate knowledge and understanding of the general classification of antibiotics and be familiar with several members from each class
understand the mechanism of action for each major class of antibiotic
understand side effects of the commonly used antibiotics, including specific drug interactions demonstrate understanding of drug allergy and hypersensitivity
have a basic understanding of an appropriate antibiotic in common conditions
understand the basic factors that drive evolution of antimicrobial resistance including spontaneous mutation, horizontal transfer of resistance genes, use of antimicrobials and selective pressure
be aware of antimicrobial resistance as a threat to public health including multidrug resistant gram negative organisms and MRSA
be aware of the impact of antimicrobial resistance on clinical outcomes, including increased clinical complications and mortality

Explain what the beta-lactam antibiotics are, and which types of infection we usually use them for?
Outline the mechanism of action of beta-lactam antibiotics…
Here’s a diagram comparing all the different beta-lactam antibiotics…
What are the adverse effects of beta-lactams?
How common is a type I hypersensitivity reaction to penicillin, and how does it develop?
Look at a type IV hypersensitivity reaction…
Why is B-lactam allergy kind of dodgy with patients?
How is cross reactivity in patients who are allergic to penicillin?
Explain what amoxicillin is, and what it’s derived from…
How can bacteria become resistant to beta-lactams?